Influence of PLGA nanoparticles on the deposition of model water-soluble biocompatible polymers by dip coating

This work relies on the use of dip-coating at various withdrawal speeds to form nanocomposite films, with a detailed analysis influence mode deposition nanoparticle (NP) concentration in dried film. While polymer solutions one hand and colloidal suspensions NPs other have been separately studied by dip coating, their combination is far being simple superposition two separate behaviors. The formation thin films composed model water-soluble biocompatible polymers (polyvinyl alcohol - PVA polyvinylpyrrolidone PVP) loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) was through coating process. Flat silicon substrates were removed controlled speed from an aqueous suspension. Thin PLGA concentrations ranging 1 10 % wt./wt. or PVP matrices prepared. presence well-established process film examined, as well regime deposited coating. We demonstrate that dispersion water solution does not modify A typical “V” shaped curve observed, well-known regimes: capillary draining modes respectively obtained low high speeds. Due crystallization (favored slow evaporation solvent) it possible identify individual AFM case matrice. Amorphous successfully prepared allowed us AFM. Because prevalence evaporation-driven phenomenon speed, incorporation observed over whole range speeds, showing original behavior compared recent studies relying pure Landau-Levich (i.e. non-evaporative systems). Our results indicate equally retrieved regimes. suggests balance between viscous drag interfacial effects depends calls for more physical processes involved both